Original PDF Ebook – Human Drug Metabolism3rd Edition – 9781119458562

Original PDF Ebook – Human Drug Metabolism3rd Edition – 9781119458562

Provides a timely update to a key textbook on human drug metabolism_x000D_
The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact._x000D_
Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s._x000D_
Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact_x000D_
Reflects refinements in the author’s teaching method, particularly with respect to helping students understand biological systems and how they operate_x000D_
Illustrates the growing relationship between drug metabolism and personalized medicine_x000D_
Includes recent developments in drug discovery, genomics, and stem cell technologies