Original PDF Ebook – Antibiotics2nd EditionChallenges, Mechanisms, Opportunities – 9781555819309

Original PDF Ebook – Antibiotics2nd EditionChallenges, Mechanisms, Opportunities – 9781555819309

A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance_x000D_
Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets._x000D_
This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics._x000D_
Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions:_x000D_
What are antibiotics?_x000D_
Where do antibiotics come from?_x000D_
How do antibiotics work?_x000D_
Why do antibiotics stop working?_x000D_
How should our limited inventory of effective antibiotics be addressed?_x000D_
Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.